Oral route provides substance information on the substance’s acute toxicity via the oral route. Aliquam nec erat semper, suscipit libero et, bibendum mauris. These acids experience two-step dissociation in aqueous solutions.They have the same structural formula but different spatial configurations. Units and data are normalised when possible and therefore the unit of measure/order of magnitude in the Brief Profile data may not correspond exactly to the one in the registered dossier. Values provided in ppb and Vol% are provided separately. level’ as the dose descriptor. This section summarises the values related to distribution modelling from all registered dossiers for the substance. List of substances subject to the POPs Regulation - Indicates if the substance is included in the POPs Regulation. This section summarises the values related to toxicity to soil macroorganisms (except arthropods) from all registered dossiers for the substance. Y is the check-digit calculated in accordance with the 10-digit ISBN method. Displayed are the RANGES of min – max of values (provided in %). REACH and/or CLP notifiers may classify a substance differently based on different studies or the way they access the data. machine wash liquids/detergents, automotive care products, paints and coating or adhesives, fragrances and air fresheners) and outdoor use. See ‘Summary oral systemic effects’, except: ‘See Summary inhalation systemic effects’. Recall from Section 1.10B that there is restricted rotation around carbon–carbon double bonds. Registrants can register their substance explosiveness as: This section summarises the oxidising values from all registered dossiers for the substance. EC50/LC50 for microorganisms provides substance information on the substance’s effect concentration or lethal concentration for 50% of the microorganisms in the test, generally displayed in milligram per litre. LC50 for marine water invertebrates provides substance information on the substance’s lethal concentration for 50% of the marine water invertebrates in the test, displayed in milligram per litre. Information on the most sensitive study can be provided by the registrants as: Dermal exposure provides information on the substance’s hazard assessment conclusions regarding dermal exposure (for workers). Due to ongoing appeals, all registrations flagged as revoked are published as, In the case of a merge between two companies having a registration for the same substance, the higher tonnage band registration is maintained as active, and the other registration is, Stability in organic solvents and identity of relevant degradation products, Storage stability and reactivity towards container material, Environmental data (monitoring data/field studies), Additional information on environmental fate and behaviour, Skin irritation/corrosion (study results), Respiratory sensitisation (study results), Repeating dose toxicity oral/inhalation/dermal/other routes (study results), EINECS (European INventory of Existing Commercial chemical Substances) List, ELINCS (European LIst of Notified Chemical Substances) List. 215–540–4, is covered by three harmonisations – 005–011–00–4; 005–011–01–1; 005–011–02–9), CLH information cannot be displayed in the Brief Profile as the differences between the CLH classifications require manual verification. Bioaccumulation Factor (aquatic species) L/kg ww provides substance information on the substance’s bioaccumulative properties for aquatic species measured in litre per kilogram  (wet weight). If more than one result is available per endpoint, the range of results (min-max, RANGE method) will be presented. Overview of Structure Of Fumaric Acid, Fumaric acid is an organic compound that is white and has a general formula of H O 2 C C H = C H C O 2 H \mathrm{HO}_{2} \mathrm{CCH}=\mathrm{CHCO}_{2} \mathrm{H} H O 2 C C H = C H C O 2 H Note that translated names are available at this time only for substances which have a harmonised C&L or which are approved Biocidal active substances. Within the context of REACH, impurities are unintended constituents present in a substance as manufactured. Data for workers – eye exposure provides information on the substance’s hazard assessment conclusions regarding eye exposure (for workers). Note: If a temperature value is not provided by the registrant, the information on half-life in water will not be processed for the Brief Profiles. This substance is used in the following activities or processes at workplace: transfer of chemicals, transfer of substance into small containers, mixing in open batch processes and closed batch processing in synthesis or formulation. The CLP Regulation makes sure that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union. The Restriction list describes the conditions for the manufacture, placing on the market or use of certain substances, either on their own or in mixtures or articles. Bioaccumulation Factor (terrestrial species) L/kg ww provides substance information on the substance’s terrestrial bioaccumulative properties measured in litre per kilogram (wet weight). The information provided in the free-text fields is not published in the Brief Profiles. If so, the data provided is not processed for the Brief Profile. Solubility in organic solvents / fat solubility. Hazard to aquatic organisms provides information on the substance’s hazard assessment conclusion regarding aquatic organisms. Maleic acid is an organic compound which is a dicarboxylic acid (molecule with two carboxyl groups).Maleic acid is the cis isomer of butenedioic acid, whereas fumaric acid is the trans isomer. Other industrial uses of fumaric acid are in jet printing inks, plastics surface coating and paper sizing, and as an intermediate in the preparation of unsaturated polyester and alkyd resins. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. The absence of an interaction does not necessarily mean no interactions exist. This section provides an overview of the type of study records behind the presented results and data waving justifications. Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. See the official IUPAC website for more information on the International Union of Pure and Applied Chemistry. The Agency thus cannot guarantee the correctness of the information displayed. This information has not been reviewed or verified by ECHA, and may change without prior notice. 2(b)(i) - Hazardous Agents, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, FCM and Articles Regulation, Annex I - Authorised Substances, Workplace Signs - minimum requirements & signs on containers and pipes, kwas trans-etyleno-1,2-dikarboksylowy (pl), C&L Inventory, Registration dossier, Other, fumaric acid ,Butenedioic acid , Allomaleic acid , Boletic acid , Donitic acid , Lichenic acid, EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. LC50 for freshwater fish provides substance information on the substance’s lethal concentration for 50% of the freshwater fish in the test, displayed in milligram per litre. The Candidate List includes substances that are subject to additional protocols and reporting obligations and which may eventually be included in the Authorisation list, further limiting their use. Therefore, data has to fit the format and aggregation logic that is used for the Brief Profile. For this endpoint registrants do not provide study result data. The basis of SMILES is the representation of a valence model of a molecule. Registrant can provide information on eye exposure as mentioned above for ‘Data for workers – eye exposure.’. The light blue bar illustrates the percentage of matching substance classifications provided by manufacturers and importers in CLP notifications. The number of studies provided is indicated by ‘[x] studies submitted’, while the actual number of studies processed for the endpoint is indicated by ‘[x] studies processed’. If so, the data provided is not processed for the Brief Profile. LC50 for freshwater algae provides substance information on the substance’s lethal concentration for 50% of the freshwater algae in the test, displayed in generally milligram per litre. Log Pow provides substance information on the partition coefficient type Pow at a temperature measured in °C and acidity in pH. Applicant’s summary and conclusion – Interpretation of results (dermal). Authorisation list (Annex XIV) – indicates if the substance is included in the Authorisation List. Dynamic viscosity at 20°C provides substance information on the substance’s (dynamic) viscosity per millipascal second at a temperature of 20°C. The pKa values of fumaric acid are 3.03 and 4.54(3), indicating that this compound will exist almost entirely in anion form in the environment and anions generally do not adsorb more strongly to soils containing organic carbon and clay than their neutral counterparts(4). Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below. there is no manual verification or assessment of the correctness of the data. Release to the environment of this substance can occur from industrial use: formulation of mixtures, in processing aids at industrial sites and in the production of articles. Thirdly the display of data is prioritised by unit. This section summarises the Ecotoxicological information provided from all registered dossiers for the substance. This section displays the values related to repeated dose toxicity from all registered dossiers for the substance. If so, the data provided is not processed for the Brief Profile. Nat Rev Drug Discov. If so, the data provided is not processed for the Brief Profile. Note: Registrants can also select ‘other’ as the type of density. If more than one IUPAC name is available from REACH registered dossiers, all IUPAC names are displayed in ‘Other names’ section of the Brief Profile. If you believe you are experiencing an interaction, contact a healthcare provider immediately. The substance identifiers – if available and not claimed confidential – displayed in the ’Substance identity’ section of the Brief Profile are: In addition, information on the type of substance, origin, number and type of registered compositions and other places where the substance is listed are displayed in this section. pH provides substance information on the substance’s acidity level measured in pH at a temperature measured in °C and a concentration measured in (milli)grams per litre. Seven carboxylic acids are separated based on their polarity and pKa values. Registrants can choose from the following picklist endpoint conclusions: If an adverse effect is observed, data can be provided as LD 50 or discriminating concentration, displayed here in milligram per cubic metre. Nat Rev Drug Discov. This section summarises the values related to toxicity to sediment toxicity from all registered dossiers for the substance. EC10 / LC10 or NOEC for freshwater sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the freshwater sediment or the no observed effect concentration for of the model organisms feeding off the freshwater sediment. InChI=1S/C4H4O4/c5-3(6)1-2-4(7)8/h1-2H,(H,5,6)(H,7,8)/b2-1+. Additives are the RANGES of min – max of the substance a distinct classification and labelling ( CLP00 ) by! Assessment of the impurities and additives InChI is an organic compound that a! 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