Tener > 20 % de sitios con gingivitis, > 5 % de sitios con retracción gingival y > 70 % de sitios con pérdida de inserción periodontal > 2 mm, incrementó la media esperada de dientes perdidos a 70.6, 156.4 y 86.9 %, respectivamente. They are considered surrogate variables because changes in their status are interpreted to have an impact on the ultimate goal of periodontal therapy, which is tooth retention. Evaluating the individuals to determine their baseline risk for a specific disease, current health status and thereby predicting the occurrence of disease in future constitute the prospective, Infectious Disease Clinics of North America. In this retrospective study, the efficacy of periodontal therapy and maintenance in preventing tooth loss was evaluated. Neither PI, history of smoking, or history of betel nut use were significantly associated with attachment loss over time. The number of teeth lost in the three prognostic categories was: one (0.07%) for teeth with good prognoses, 21 (3.63%) for questionable prognoses and 22 (11.34%) for hopeless prognoses. The results of this study indicate that some clinical factors used in the assignment of prognoses are clearly associated with changes in clinical condition over time. Once all of the steps of the treatment plan have been carried out, the microbiological test is then repeated to certify that the mouth has regained a healthy ecosystem, hence showing a clear prevalence of saprophytes and a level of percentage of pathogens that the immune system is able to easily manage. The method of generalized estimating equations (GEE) for correlated data was utilized to determine the relationship of each clinical factor to the assignment of initial prognosis, improvement in prognosis at 5 years, and worsening in prognosis at 5 years. Other variables included age, history of smoking and betel nut use. Previous studies of periodontal prognosis have established that regardless of the treatment, the most important modifier of periodontal disease progression is the patient.2, 3 Due to patient-level modifiers (PLMs) such as genetics, smoking, and diabetes, there will always be a subset of patients at increased risk of tooth loss regardless of the treatment provided. Compared with PPD